San Francisco (2-0) is eyeing just its second 3-0 start in the past five years.
What Impact Will Kyle Juszczyk and Siran Neal Have Sunday?
Niners fans know Juszczyk as an unsung hero, particularly as the lead blocker for Christian McCaffrey.
With Mac Jones potentially serving as the starting quarterback in a divisional game — against Arizona, who walked into Santa Clara and won — and Jauan Jennings missing practice Friday, having Juszczyk available as both blocker and pass-catcher will be huge.
Juszczyk has three catches for 37 yards this season, including one for five in San Francisco’s 26-21 Week 2 win over the New Orleans Saints on Sunday — which Jones also started.
As for Neal, he has primarily been a special-teams player, since he has only one tackle and has not played a defensive snap this season. Yet, he has played 35 special-teams snaps thus far in 2025.
Yet, Neal is listed as the backup free safety to Jason Pinnock on the 49ers depth chart and has played both cornerback and safety in his career. That means he will be available in case of injury.
Is Brock Purdy Playing Sunday?
Though Mac Jones still took starting-quarterback reps, and franchise quarterback Brock Purdy was slated to miss two-to-four weeks with shoulder and toe injuries according to reports, Purdy still may suit up for the showdown between 2-0 teams Sunday.
“It’s been a day-to-day thing this week, and I feel like I’m happy with the progress that I’ve been making with my foot and toe,” Purdy said. “So more than anything, it’s just going to be a day-to-day thing on how I feel.”
Purdy’s optimism was met with a cold dose of water from 49ers coach Kyle Shanahan, who seems more interested in keeping Purdy progressing — and maybe dressing for the game Sunday — rather than shoe-horning him into the team’s starting lineup.
“I thought he had a good week. Hopefully we can get him up for the game,” Shanahan said. “Just see how he does tomorrow. Just talking to him, I think it’s highly unlikely that he’ll start, but just trying to see where he’s at to see if he could be a [backup] or an emergency three (quarterback).”
Whoever plays quarterback for San Francisco will again have his blindside protected by one of the greatest left tackles to ever play. Trent Williams, like Neal and Juszczyk, was elevated to a full practice participant Friday, meaning he is likely to play Sunday.
Williams is battling a knee injury by has started each of the Niners’ first two games and earned the 18th-best rating from Pro-Football Focus among tackles through two weeks (70.6).